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Assessing Median Nerve Regeneration in Rodent Models– A Systematic Review

Wed, 01 Jan 2025 00:00:00 GMT

Title: Assessing Median Nerve Regeneration in Rodent Models– A Systematic Review Authors: S, Dhanusia; Umasankar, Yamini; Suganthirababu, Prathap; S, Santhana Lakshmi; Parveen, Asma Abstract: Peripheral nerve injuries (PNI), particularly median nerve injuries, lead to significant motor and sensory impairments, affecting daily function and quality of life. Rodent models are extensively used for studying nerve regeneration due to their physiological similarity to humans. Accurate assessment of nerve regeneration is critical for evaluating therapeutic approaches, yet existing methods lack standardization and comprehensive analysis. A systematic review was conducted following PRISMA guidelines, searching databases including PubMed, Google scholar and science direct from 2013 to 2024. Inclusion criteria focused on studies using rodent models to investigate median nerve regeneration with surgical interventions and reporting functional, physiological, histomorphometry, or molecular outcomes. Out of 110 studies, 13 studies were selected and reviewed. The review identified various assessment techniques includes, Functional test evaluates motor and sensory recovery. Electrophysiological test measure nerve conduction velocity and muscle action potentials. Histological analyses examine nerve morphology, myelination, and axonal regeneration. Molecular methods assess gene expression and protein markers. A multimodal approach combining these methods provides the most comprehensive evaluation of nerve regeneration. This systematic review highlights the current state of median nerve regeneration in rodent models. The results suggest that rodent models are a valuable tool for studying nerve regeneration and evaluating potential therapeutic interventions. However, there is a need for standardization in the methods used to assess nerve regeneration, as well as the reporting of study results.

Physiotherapy Strength-Training Interventions In Juvenile Idiopathic Arthritis : A Narrative Review

Sat, 04 Oct 2025 00:00:00 GMT

Title: Physiotherapy Strength-Training Interventions In Juvenile Idiopathic Arthritis : A Narrative Review Authors: JOSHI, SHASHWAT; BARIK, SANJEEVINI; PATRA, CHINMAYA KUMAR Abstract: Background: Juvenile idiopathic arthritis (JIA) frequently leads to muscle weakness, decreased bone density, fatigue, and diminished physical function in affected children [1]. Strength training guided by physiotherapy—including activities such as active virtual reality (AcVR), weight-bearing exercises, resistance training, and core stability work—may help address these challenges Objective: To review and synthesize evidence from 2017–2025 on physiotherapy-guided strength training interventions in children with JIA, focusing on safety, feasibility, musculoskeletal outcomes, functional benefits, and adherence challenges. Methods: A narrative review was conducted with systematic search principles across PubMed, PEDro, Web of Science, and Scopus (2017–June 2025). Randomized controlled trials (RCTs), feasibility studies, and pilot studies were included if they involved physiotherapist-supervised strength or resistance training interventions in JIA populations. Methodological quality was assessed using the Josephkin Kennedy KNN tool. A total of seven studies (n=143 participants) were included. Results: Strength training was consistently safe, with no serious adverse events reported. Improvements were observed in muscle structure (fascicle length, thickness, pennation angle), torque, bone mineral density, and functional performance (6MWT, stair climb, fatigue reduction). Adherence rates varied widely (47–95%), influencing outcomes. Digital interventions, internet-based platforms, and serious gaming showed promise in enhancing motivation and adherence. Physiotherapy-led strength training is safe and effective for improving musculoskeletal and functional outcomes in children with JIA. Adherence remains the primary barrier, underscoring the need for innovative, engaging, and scalable intervention strategies. Future research should focus on standardized protocols, longterm outcomes, and integration of digital tools to optimize rehabilitation.

Effectiveness of Aerobic Training on Cardiopulmonary Function and Quality of Life in Children with Cerebral Palsy: A Single-Blinded Randomized Trial

Thu, 25 Sep 2025 00:00:00 GMT

Title: Effectiveness of Aerobic Training on Cardiopulmonary Function and Quality of Life in Children with Cerebral Palsy: A Single-Blinded Randomized Trial Authors: Mukherjee, Prathana; Das, Partha Ranjan; Pradhan, Deepak Kumar; Sahoo, Rajesh; Mishra, Priyadarshini Abstract: Background: Children with cerebral palsy (CP) often experience reduced cardiopulmonary endurance and physical activity levels, which can lead to longterm health complications. This study aimed to evaluate the effects of aerobic exercise combined with conventional physiotherapy on cardiopulmonary endurance in children with CP. Methods: A two-group experimental pretest post-test design was utilized, involving 32 children aged 4 to 14 years diagnosed with CP at GMFCS levels I and II. Participants were randomly assigned to an experimental group, which received aerobic exercises in addition to conventional physiotherapy, and a control group that received only conventional physiotherapy. The intervention lasted six weeks, with assessments conducted before and after the treatment period. Key outcome measures included the 6-minute walk test (6MWT), walking speed, heart rate, and energy expenditure index (EEI). Results: The experimental group demonstrated significant improvements in the distance covered during the 6MWT, walking speed, and EEI compared to the control group. Statistical analysis revealed that the inclusion of aerobic exercises led to more pronounced enhancements in cardiopulmonary endurance and overall physical capabilities. Conclusion: The findings suggest that aerobic exercise, when integrated into rehabilitation programs for children with CP, significantly improves cardiopulmonary endurance and physical fitness. This study supports the incorporation of structured aerobic training as a vital component of therapeutic interventions, promoting better health outcomes and quality of life for children with cerebral palsy.

PNF-Augumented Balance Training Using Balance Beam and Balance Board: A Controlled Trail Assessing Walking Speed Outcomes in Stroke Patients

Wed, 01 Jan 2025 00:00:00 GMT

Title: PNF-Augumented Balance Training Using Balance Beam and Balance Board: A Controlled Trail Assessing Walking Speed Outcomes in Stroke Patients Authors: Sahoo, R; Das, PR; Pradhan, DK; Mukherjee, P; Parveen, A; Sahoo, AC Abstract: Background & purpose: Stroke is a vulnerable condition having a high global prevalent rate. Balance impairment is a major antagonist to the disease progression. The current study aimed to compare two balance training program (balance board and balance beam training) on gait parameters in stroke patients. Methods: The randomized trial was conducted among 100 stroke survivors. They were allocated in to two groups either the balance beam or the balance board training group. All the participants were undergone eight weeks of supervised training session. The gait velocity was assessed using the Time Up and Go (TUG) test at the baseline and post training. Results: The result of the study revealed that both the group has showed significant improvements in the gait parameters (p < 0.05). However, the balance beam training group had statistically significant better gait velocity than the balance training group (p < 0.05). Conclusion: The study concluded that balance training is an essential component in improving gait velocity during stroke rehabilitation. The clinicians can use either of the treatme